Christian Rolfo, MD, PhD, of Mount Sinai Medical Center (now at Ohio State as Chief of Oncology), explores the science and clinical applications of liquid biopsies, including circulating tumor DNA. On this special Healthcare Unfiltered episode, he explains how this cutting-edge approach compares to traditional tissue samples in terms of concordance, sensitivity, and specificity, and expands on the methods used to distinguish signal from noise in liquid biopsy results.

Dr. Rolfo discusses which thoracic patients should receive liquid biopsies and the optimal timing within their care journey. He also covers the clinical decisions informed by liquid biopsy data, such as advising on adjuvant therapy, and debates the potential role of liquid biopsies in screening and early detection for healthy individuals.