On this special episode, Chadi hosts three phenomenal physicians to help us better understand the complexity of designing and executing clinical trials. Hira Mian, MD, faculty of health sciences, McMaster University (Canada), and Murali Janakiram, MD, MS, assistant professor, City of Hope, both faced and continue to face challenges in bringing their clinical trial ideas to light. Saad Usmani, MD, MBA, FACP, chief of myeloma service, Memorial Sloan Kettering Cancer Center, joins as a senior investigator to shed light on the journey and to advise both junior faculty on what can be done next. The group reacts to trial ideas they’ve each had and continue to funding roadblocks. They consider how long down the road researchers should look when formulating a clinical trial design, how limited funding availability figures to be a lasting barrier for many important study ideas, how junior faculty members are vying for such funding to get published research under their belt and earn promotions, and so many more intricacies involved in the clinical trial landscape. This is a perfect episode for anyone interested in clinical trials and wanting to understand the role of a clinician investigator.