Chadi sits down with Dr. Sairah Ahmed just ahead of the ASH Annual Meeting for a comprehensive deep dive into the state of Hodgkin Lymphoma management in 2026. Dr. Ahmed walks through how clinicians should interpret the newest data releases, revisits whether histologic subtyping still influences decision-making in an era increasingly shaped by biomarkers, and details her practical framework for approaching patients with stage I/II disease—including when and how radiation therapy still plays a meaningful role. She further explores the strength and limitations of interim PET, whether treatment should truly pivot based on those scans, and how nivolumab is now being deployed across frontline, relapsed/refractory, and post-transplant settings. Rounding out the discussion, Dr. Ahmed outlines how she manages advanced-stage disease with particular attention to insights and implications from SWOG S1826, highlights immune-related toxicities clinicians must watch for, clarifies the evolving role of autologous transplant and the preferred sequence of prior therapies, and offers an inside look at the most important agents and strategies moving through the Hodgkin Lymphoma pipeline.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Journalist Erin O’Hearn joins Chadi to share her deeply personal story as both a patient and a caregiver navigating the healthcare system for more than two decades. Drawing from her lived experiences, Erin reflects on how today’s advances in artificial intelligence could have supported her journey—easing the emotional and logistical burdens of care while improving communication and empathy between patients and providers. She offers a thoughtful and forward-looking take on the MAHA movement, as well as explores how AI should be used to enhance time spent with patients, foster genuine human-to-human connection, and help clinicians care for themselves as well as those they serve.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Dr. Debra Patt, Executive Vice President of Texas Oncology and President of the Community Oncology Alliance (COA), for an in-depth conversation about the evolving landscape of community oncology. Dr. Patt outlines her vision for bringing innovation and artificial intelligence into routine cancer care—addressing challenges from clinical decision-making to physician burnout—while ensuring equitable access to cutting-edge treatments across all practice settings. She also discusses her leadership role on the ASCO Board, her efforts to expand clinical research opportunities to smaller community sites, and how these initiatives collectively aim to advance the global standard of oncology care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi resumes his WCLC review with Dr. Eric Singhi of The University of Texas MD Anderson Cancer Center, exploring the most significant updates in mutation-driven lung cancer presented at this year’s meeting. The discussion dives into advances in sequencing and molecular profiling to identify actionable genomic alterations (AGAs) and how these findings are transforming both early- and late-stage treatment strategies. Dr. Singhi highlights key data from the ADAURA, TARGET, and NAUTIKA1 studies, as well as the expanding role of EGFR-, ALK-, BRAF-, and KRAS-targeted therapies in neoadjuvant and adjuvant settings. The conversation also examines the challenges of financial toxicity, decisions around adjuvant treatment cessation, and the nuanced management of locally advanced and stage IV EGFR-positive disease in the era of precision oncology.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Dr. Estelamari Rodriguez, thoracic oncologist at the University of Miami’s Sylvester Comprehensive Cancer Center, joins the show to break down the latest advances in non-mutation driven and small cell lung cancer presented at the World Conference on Lung Cancer (WCLC) and how they translate into everyday clinical practice. She discusses pivotal studies including the ALCHEMIST trial exploring adjuvant therapy in ALK-fusion–positive early-stage lung cancer, PACIFIC-2 assessing concurrent immunotherapy and radiation, and the FLAURA2 and MARIPOSA trials redefining targeted approaches for advanced disease. The conversation also delves into next-generation drugs transforming outcomes in extensive-stage small cell lung cancer, updates in mesothelioma, and the expanding use of liquid biopsy—now a cornerstone for diagnosis, monitoring, and guiding precision therapy for all patients.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Returning guest Dr. Amer Zeidan of Yale Medicine and Smilow Cancer Hospital joins to discuss how clinicians should approach low-risk Myelodysplastic Syndrome (MDS), which is most often managed in community settings. He breaks down how to risk-stratify patients using molecular and prognostic markers, when to treat versus observe, and his preferred first-line therapies in today’s landscape. Dr. Zeidan also delves into the COMMANDS trial and the role of luspatercept, emerging questions shaping the future of low-risk MDS management, and offers a preview of high-risk MDS developments, including insights from the VERONA study.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Returning guest Jill Feldman, a prominent lung cancer survivor and patient advocate, shares her reflections on the World Conference on Lung Cancer (WCLC) from a patient’s point of view. She discusses how patients and advocates interpret complex scientific data, why attending conferences like WCLC is vital for bridging the gap between research and real-world experience, and how the dialogue between scientists and patients continues to evolve. Jill also highlights key takeaways from the meeting, including the growing focus on survivorship and the need for a more patient-centered lexicon when communicating about side effects and treatment outcomes.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Investigative journalist and New York Times bestselling author Gardiner Harris joins the podcast to dive deep into his groundbreaking book, “No More Tears: The Dark Secrets of Johnson & Johnson.” Harris recounts the extensive research and challenges behind uncovering how J&J—long regarded as a trusted “goliath” of American healthcare—played a far greater role in fueling the opioid epidemic than Purdue Pharma, a contribution he argues led to more than two million American deaths yet received a fraction of the public scrutiny. He discusses the pushback he faced while exposing the company’s practices, critiques how the FDA failed to act more decisively, and examines the intersection of profit, policy, and patient safety. The conversation also touches on the modern science and marketing of Tylenol, revealing how deep the influence of corporate power runs in shaping public health narratives.View more about the book.https://gardinerharris.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Returning guest Anthony DiGiorgio, DO, a practicing neurosurgeon at UCSF and noted health policy commentator, takes a deep dive into the 340B Drug Pricing Program—one of the most consequential yet misunderstood mechanisms in US healthcare. He traces the program’s origins in the early 1990s, designed to help safety net hospitals stretch scarce federal resources to better serve vulnerable patients. Dr. DiGiorgio examines how, over time, many institutions have leveraged 340B as an ancillary revenue stream rather than a patient-centered support system, detailing when and how these practices emerged, the financial incentives at play, and the consequences for both physicians and patients. He also discusses current policy debates and potential reforms aimed at restoring 340B to its original mission.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Dr. Anand Patel, DO, founder of LV8 Health, walks us through the philosophy and mechanics of concierge-style longevity medicine. He explains how LV8 applies Medicine 3.0, combining precision diagnostics (DEXA, VO₂ max, resting metabolic rate, advanced blood panels) with regenerative and geroprotective therapies, nutrition, fitness, and sleep optimization. You’ll hear how he translates data from wearables and diagnostics into bespoke plans, how he helps patients sustain behavior change, and how he answers critics who question the scientific basis of his approach.View the LV8 website.https://www.lv8.health/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. https://www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. https://www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Gavin MacBeath, CEO of TScan Therapeutics, takes us inside his journey from scientist to biotech leader and what it means to build and run a therapeutic development company at the cutting edge of immuno-oncology. He breaks down how TScan’s platform works to discover and match T-cell receptors (TCRs) with their antigens, and why TCR-T therapies may provide distinct benefits over CAR-T approaches, especially when tackling solid tumors. He also discusses which diseases are most likely to respond to TCR therapies and shares the latest updates on TScan’s clinical programs, from early-phase trials to an upcoming phase III study poised to shape the future of cancer treatment.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Dr. Sameer Keole, radiation oncologist at Mayo Clinic Arizona and president of ASTRO, joins the show to preview the upcoming ASTRO Annual Meeting and its key themes. He reflects on his presidential term, discussing accomplishments, lessons learned, and initiatives like his “defense to offense” vision and community outreach efforts. Dr. Keole also tackles hot-button topics in radiation oncology, including the evolving roles of proton therapy and artificial intelligence in patient care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In this follow-up episode, Dr. Ed Livingston—renowned surgeon, educator, researcher, and former deputy editor at JAMA—returns to discuss the latest developments in his ongoing legal battle. He reflects on what has transpired in the three months since his last appearance, offering insights into the discovery process and the legal details shaping the case as it heads toward a July 2026 trial date.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA ]]>

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Dr. Douglas Flora, Executive Medical Director of Oncology Services at St. Elizabeth Healthcare Cancer Center and Editor-in-Chief of the journal AI in Precision Oncology, shares his pragmatic perspective on how AI is reshaping cancer care today and tomorrow. He discusses real-world applications such as FDA-approved pattern recognition tools in imaging and pathology, how AI may soon integrate with ctDNA to guide treatment decisions, and the clinical trials needed to advance this field. Dr. Flora also highlights how AI can enhance decision support in community oncology, expand care access in rural areas, and what his journal is doing to engage clinicians, researchers, and innovators in this rapidly evolving space.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Monique Diaz, Chief Medical Informatics Officer at CommonSpirit Health, unpacks the intersection of big data, clinical care, and healthcare innovation. She shares how informatics transforms resource allocation, patient engagement, and system efficiency—while offering a behind-the-scenes look at the daily responsibilities of a CMIO, from EMR coding to AI integration. Dr. Diaz also explores the evolving relationship between informatics and AI, and how future advancements hinge on ethical frameworks and responsible governance.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Sandy Scheinbaum, founder of the Functional Medicine Coaching Academy, joins the show to break down the principles of functional medicine—a patient-centered approach that integrates lifestyle, nutrition, psychology, and mind-body practices to address the root causes of illness. She shares how her academy trains coaches to guide individuals through sustainable behavior change, explains how mental and emotional states can directly impact physical symptoms, and discusses why functional medicine is especially critical in today’s world, where chronic stress, isolation, and lifestyle-related conditions are on the rise. Dr. Scheinbaum also highlights which patients benefit most from this approach and how functional medicine empowers people to take control of their health beyond traditional medical models.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Anthony DiGiorgio, a neurosurgeon at UCSF with a strong interest in healthcare policy, joins the show to unpack the complex and often misunderstood world of Medicaid. In a wide-ranging and nuanced discussion, he explores who qualifies for coverage, why most Medicaid spending goes to groups people don’t typically expect, and whether the system should be expanded or fundamentally reformed. Dr. DiGiorgio outlines his support for a robust safety net, emphasizing targeted subsidies over a government-run program, and offers his take on the proposed “Big Beautiful Bill” currently in Congress. Along the way, the conversation touches on broader healthcare issues including the 340B drug discount program, the Affordable Care Act, and the role of the free market in ensuring access to care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Ed Livingston, renowned surgeon, educator, and researcher, who was a former deputy editor at JAMA, found himself out of a job after a JAMA podcast he hosted with Dr. Mitch Katz that discussed, among other items, structural racism as a contributor to the high mortality in minorities from COVID. This incident led to a series of lawsuits, some of which were highly publicized.Ed shares behind the scenes events, incidents, and what transpired in 2021, and how the AMA handled the situation. In this episode, Ed shares his background, career path, passion for education and medicine, and his disappointment at how everything was handled by the AMA.This is a rare discussion with some information being shared for the first time ever with listeners and viewers.The AMA declined the request to comment and provide their side of the story.Superior court ruling Livingston v AMA (AMA declares that physicians not entitled to due process, rules that the AMA committed libel and defamation): https://rulings.law/rulings/judge-curtis-a-kin/22stcv09441-2022-10-13.htmlUnanimous Appellate decision regarding libel and defamation by the AMA, Adds an additional finding of false light and invasion of privacy https://www4.courts.ca.gov/opinions/nonpub/B324638.PDFX post summarizing the Appellate decision (the court refers to the AMA as disingenuous): https://x.com/ehlJAMA/status/1852551140799291817Article summarizing the Appellate decision (““[d]rawing all reasonable inferences in his favor, Livingston has made a prima facie case that the gist or sting of the accusation in statement [that the podcast ‘denied the existence of structural racism in medicine,’ was not true.”): http://www.metnews.com/articles/2024/defamation_11042024.htmCourt orders Livingston to pay $110,000 to AMA despite his prevailing on the key allegations: https://rulings.law/rulings/judge-joseph-lipner/22stcv09441-2025-04-08.htmlArticle from the lawyer representing the AMA declaring that the process the AMA used against Livingston is abused “the widely abused anti-SLAPP statute.”: https://www.law.com/therecorder/2019/06/03/calif-high-court-ruling-good-news-for-defamation-plaintiffs/?slreturn=20250722074004X post with links to the various rulings: https://x.com/ehlJAMA/status/1913584194405425374Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Ben Casavant, co-founder and CEO of Tasso, joins the show to discuss how he transformed the idea of patient-led blood collection into a reality through devices like Tasso+. He explains how Tasso’s self-collection kits—designed to be easy, virtually painless, and used anytime at home—solve the scalability issues of mobile phlebotomy while improving patient convenience, adherence, and access to care. Casavant also details the company’s growth journey, its FDA-cleared and CE-marked products, the broad customer base that includes healthcare providers, labs, insurers, and pharma companies, and how Tasso adds value not only through affordability, but by streamlining logistics, boosting compliance, and enabling seamless integration of patient-collected data into care systems.Read more about Tasso.https://www.tassoinc.com/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Pallawi Torka of Memorial Sloan Kettering Cancer Center joins to share highlights from ASCO and EHA 2025 on the evolving landscape of B-cell lymphomas, including Hodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma. She offers in-depth insights on the STARGLO study and its recent ODAC review, the POLARGO trial, a rare T-cell leukemia (T-LGL) study, and new data supporting nivolumab-AVD in frontline Hodgkin lymphoma. Additional discussion includes the inMIND trial for follicular lymphoma, the growing role of ctDNA in managing DLBCL, advances in CAR-T cell therapy for CNS lymphoma, and how she is adapting treatment strategies based on favorable vs. unfavorable disease features.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Ben Derman of the University of Chicago Medicine joins the show to unpack major updates in multiple myeloma presented at ASCO and EHA 2025. He discusses the growing role of quadruple therapy across all patient populations and its implications for the future of autologous stem cell transplant, including insights from the MIDAS trial on MRD-guided transplant decisions. Additional highlights include MRD-negativity as a potential off-ramp for maintenance therapy, evolving data from frontline triplet vs. quadruplet studies, real-world referral trends, CARTITUDE-4 subgroup outcomes, and the expanding utility of bispecifics and trispecific antibodies, particularly for extramedullary disease.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Joe DePinto, MBA, Head of Cell, Gene & Advanced Therapies at McKesson, joins the show to discuss InspiroGene, McKesson’s end-to-end platform built to address the complex delivery, coordination, and commercialization needs of cell and gene therapies. He breaks down how InspiroGene integrates logistics, specialty pharmacy, patient support services, and real-time data tracking to close critical gaps in the CGT ecosystem—especially around why many eligible patients are still not being identified, referred, or treated. He also explores the broader vision: enabling scalable access to these therapies as they move from rare diseases to larger populations, and what it will take—from providers, payers, and pharma—to meet that future.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Lou Weisbach, entrepreneur and founder of the American Center for Cures, who shares his ambitious mission to raise $750 billion through an innovative public-private bond model to accelerate the prevention and cure of chronic diseases like cancer, Alzheimer's, diabetes, and Parkinson’s. Weisbach discusses how his model is designed to align incentives across government, industry, and research institutions, bridging political divides and pharmaceutical interests to focus on cure-based rather than treatment-based outcomes. He also reflects on two decades of groundwork, key milestones achieved, and how the initiative operates day-to-day, including the development of disease-specific platforms poised to transform biomedical research and public health.Find out more about his cause.https://theamericancenterforcures.org/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Vivek Subbiah returns for another edition of Vivek’s Takes, offering his expert insights on the standout science from the 2025 ASCO Annual Meeting. He breaks down key developments including trispecific antibodies, the growing role of radioligand therapies, a new standard of care in small cell lung cancer, and paradigm-shifting data in adjuvant therapy for colorectal cancer. The discussion also highlights a long-term exercise intervention, adjuvant vaccine studies, ctDNA and MRD integration, resistance mechanisms, artificial intelligence, and other emerging trends shaping the future of oncology.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dena Marrinucci, PhD, co-founder and COO of Truvian Health, joins the show to discuss her mission to transform blood diagnostics through a point-of-care device that delivers rapid, actionable results. She shares the origin story of founding Truvian in 2015—coincidentally just weeks before the Theranos exposé—and reflects on navigating industry skepticism in the post-Theranos landscape. Marrinucci also outlines the company’s FDA submission process, the importance of empowering immediate patient-provider decision-making, and what the initial panel of 30+ lab tests offers for routine care, among so much more.Read the article on the Truvian Health blood test.https://www.newsweek.com/truvian-lab-company-blood-test-device-theranos-health-care-1997422Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Former FDA Commissioner Robert Califf returns to the show for an in-depth discussion on the integration of artificial intelligence into regulatory processes, including how AI is currently being used—and should be used—in drug and medical device approvals, the detection and review of fraudulent data, and clinical decision support systems. He also explores the boundaries between algorithmic automation and human judgment, emphasizing the importance of maintaining transparency, accountability, and trust in an increasingly data-driven regulatory landscape.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Last week, Chadi and researchers explored the KETO-CTA study, which investigated the effects of the ketogenic diet on coronary plaque formation in Lean Mass Hyper-Responders (LMHR), or individuals who experience significant LDL cholesterol elevations on low-carb diets.This week, the other side of the conversation is presented.A leading cardiologist joins the show to critically examine the KETO-CTA study findings, questioning their clinical significance and broader applicability. What do these results really mean for cardiovascular risk in the general population? Should elevated LDL in the context of good metabolic health be treated the same as traditional hyperlipidemia?This episode dives into the nuances of lipidology, the role of LDL in atherosclerosis, and the complexity of applying study findings to real-world patients.Whether you're a clinician, researcher, or just interested in the science behind diet and heart health, this conversation is essential listening.View the KETO-CTA study.https://www.sciencedirect.com/science/article/pii/S2772963X25001036Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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The ketogenic (keto) diet has surged in popularity, with many touting its weight loss and metabolic benefits. However, some individuals—particularly those following a low-carb, high-fat regimen—experience a significant rise in LDL cholesterol, a phenomenon now known as the Lean Mass Hyper-Responder (LMHR) phenotype. What does this mean for cardiovascular risk?In this episode, Chadi is joined by three of the lead investigators of the KETO-CTA study, recently published in The American Journal of Clinical Nutrition. They break down their findings on how the keto diet affects coronary plaque formation and what it could mean for LMHR individuals.This is Part 1 of a two-part series. Next week, Chadi brings in a contrasting perspective on the study’s conclusions.A must-listen series for anyone interested in the intersection of diet, cholesterol, and cardiovascular health.View the KETO-CTA study.https://www.sciencedirect.com/science/article/pii/S2772963X25001036Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Cardiologists Andrew Foy and Anish Koka return to the show for a deep and often contentious debate on one of the most pressing healthcare policy issues of our time: should the government negotiate drug prices? Using the Inflation Reduction Act (IRA) as a springboard, the conversation explores the underlying causes of inflated drug prices in the US, including the role of third-party payers, lack of transparency, and market distortions. The discussion also examines the global landscape—how other countries manage drug pricing—and whether those models offer lessons or cautionary tales. What impact will the IRA have on patients, access, and innovation? Can payers do more to control costs without sacrificing care? This episode dives into the complexities of healthcare economics, the free market, and the question of whether government intervention helps or hinders progress.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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With over 513,000 licensed advanced practice providers (APPs) in the U.S.—including 355,000 nurse practitioners and 158,470 physician assistants—and a projected 31% growth in the next five years, APPs are playing an increasingly vital role in oncology care. In this episode, Chadi is joined by Mary DiLorenzo and Clare Stone, two seasoned APPs practicing in North Carolina, for an in-depth conversation about how the field has evolved over the past 10–15 years. Together, they explore the nuances of APP scope of practice, how responsibilities vary across institutions and physician teams, and the ways in which APPs are integrated across inpatient and outpatient settings. The discussion also dives into critical questions: Are APPs seeing new patients as well as follow-ups? Could they eventually replace oncologists in some roles? What happens when clinical opinions diverge between APPs and physicians? Why do some patients feel more comfortable opening up to their APP than their oncologist? This episode offers a timely look at how APPs are shaping the future of cancer care delivery.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Drs. Emil Lou and Shruti Patel join Chadi on the podcast to unpack the alarming rise of gastrointestinal cancers in younger patients. They explore a range of possible environmental contributors—from plastic exposure and processed meats to alcohol and tobacco use—and discuss how these factors might be investigated through laboratory science. The conversation also highlights the promise of genomic profiling in shedding light on these trends, and reviews key findings from ASCO GI that could help steer future research and prevention efforts.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Drs. Sanam Loghavi and Amer Zeidan delve into the history behind the recent classification split between the World Health Organization (WHO) and the International Consensus Classification (ICC) for myeloid and lymphoid malignancies, and how a few years of minor disagreement have culminated in a unified system. They explore the critical differences in how myeloid and lymphoid neoplasms are now categorized, what this alignment means for pathologists, oncologists, regulators, and patients, when the new classification will take effect, and how it is expected to influence research, diagnosis, and clinical care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Where does AI truly fit into the future of biomedicine and healthcare, beyond the usual headlines in radiology and pathology? Jonathan Carlson, Managing Director of Research Health Futures at Microsoft, joins the show to explore the evolution of AI in medicine, from the early days to cutting-edge innovations like ambient clinical intelligence. Together, he and Chadi unpack how pretrained models and machine learning are transforming care delivery, as well as the ethical and practical questions we need to be asking now.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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A Georgia court recently awarded over $2 billion to a plaintiff who developed lymphoma due to Monsanto’s Roundup exposure, but a new bill could prevent future victims from suing the company. Patient advocate Kelly Ryerson unpacks the legal maneuvering behind this legislation, its potential impact on consumer rights, and what it means for the future of environmental and food safety. Don’t miss this critical discussion on the intersection of law, public health, and corporate accountability.For more on this, check out this article.https://www.thecentersquare.com/georgia/article_2065b5e4-1052-433d-9af8-d840389e722d.html View Kelly’s website.https://glyphosatefacts.com/about/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Mohammad Jahanzeb, a renowned oncologist specializing in lung and breast cancer who opened his own virtual second opinion clinic, joins the podcast to explore the growing need for second opinion clinics and the challenges patients face in accessing them, from financial barriers to lingering stigmas. He delves into how often second opinions lead to changes in patient management, which disease settings benefit most, and how virtual second opinion models provide expert guidance while overcoming traditional obstacles. Additionally, Dr. Jahanzeb shares his serendipitous, “Forrest Gump-like” career path, the vital role of mentorship in shaping careers, and his philosophy on avoiding “professional stagnation.”Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Simrit Parmar, founder of Cellenkos, joins the show to discuss her journey from the lab to the biotech startup world, detailing the inspiration behind launching her company, the challenges of securing funding, and the resilience required to overcome rejections. She shares insights into Cellenkos’ lead product, its progress toward market approval, and the rigorous process of demonstrating safety and efficacy to the FDA. Additionally, she provides a glimpse into the company’s pipeline of innovative cellular therapies aimed at addressing unmet medical needs.Find out more about Cellenkos.https://cellenkosinc.com/about/index.html Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Carol Rausch—a healthcare professional, cancer researcher, and former patient with lymphoma—shares how her journey from researcher to patient transformed her understanding of medical language. She discusses the impact of word choice on patients, why certain battle and war metaphors can be harmful, and how language used in clinical settings differs from what resonates with those facing a diagnosis. Carol also explores the consequences of unfiltered language on social media and her efforts to promote more thoughtful, patient-centered communication both within and beyond the healthcare community.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Drs. David Braun and Toni Choueiri join to discuss a groundbreaking Nature study on a personalized neoantigen vaccine for adjuvant renal cell carcinoma. They explore the inspiration behind the trial, how the vaccine was developed and administered, and its safety profile. The conversation also covers patient outcomes after 3-4 years, including immune responses and disease recurrence, as well as the rapid enrollment of this innovative study and what it means for the future of kidney cancer treatment.Read the publication in Nature.https://www.nature.com/articles/s41586-024-08507-5Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Jay Giri, Associate Professor of Cardiovascular Medicine at the Hospital of the University of Pennsylvania, joins the show to break down the recent NIH funding cuts and their impact on the medical research ecosystem. Together, he and Chadi explore the distinction between direct and indirect funding, the federal government's decision to reduce direct research funding to 15%, and how this shift affects researchers, institutions, and scientific progress. With growing concerns across the medical community and social media, they consider whether the backlash is justified and what the future holds for federally funded research.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Returning to the show, Drs. Vincent Rajkumar and Aaron Goodman engage in a dynamic debate over the evolving landscape of smoldering multiple myeloma, focusing on the highly anticipated study recently co-authored by Dr. Rajkumar and published in The New England Journal of Medicine after being presented at ASH 2024. They dissect the study’s findings, which highlight the impact of early intervention with daratumumab in delaying disease progression for patients classified as high-risk. The discussion explores the nuances of smoldering myeloma classification, the controversy surrounding risk stratification, and the historical context of prior studies that failed to change clinical practice. With their expert insights, Drs. Rajkumar and Goodman break down the implications of this research, questioning whether it truly shifts the standard of care and what it means for future treatment approaches.View the NEJM publication.https://www.nejm.org/doi/abs/10.1056/NEJMoa2409029Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Sakhr (Sam) Youness, a Syrian entrepreneur and engineer, provides a comprehensive primer on artificial intelligence (AI), tracing its origins from WWII-era innovations to the breakthroughs of the 1990s that shaped modern AI capabilities. He demystifies key concepts like machine learning, large language models, and the role of labeled data in training AI systems, offering insights into how AI interprets and processes human language. Dr. Youness also examines the rise of generative AI, the development of ChatGPT, and the ethical concerns surrounding AI’s proper use. Looking ahead, he discusses the next frontier—artificial general intelligence—and its implications for society, addressing the pressing question of whether AI and robotics will replace human workers. Finally, he explores AI’s evolving role in healthcare, weighing its potential to revolutionize medical advancements against the risks of misuse.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Amy Abernethy and Brad Hirsch, co-founders of Highlander Health, delve into their mission to transform healthcare through innovative, data-driven strategies. They discuss their firm's unique approach to investing in companies and technologies that advance personalized care, the creation of the Evidence Accelerator to streamline high-quality real-world data, and their efforts to solve critical challenges in building faster, more reliable demonstration projects. Furthermore, they share how they ensure credibility and quality in real-world evidence, and their vision for reshaping the future of medical innovation.Learn more about Highlander Health.https://www.highlanderhealth.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Creed McKinnon, Co-Founder and Chief Growth Officer of VersaWare, to explore how this cutting-edge startup is redefining the intersection of technology and nutrition. VersaWare’s AI-powered platform integrates voice assistants and real-time chatbot support from expert nutritionists to simplify meal building, enhance recipe discovery, and streamline pantry management. Creed shares insights into the challenges of developing a solution for users who often abandon traditional nutrition tracking apps, the innovative revenue streams behind the brand—including a consumer-friendly app—and the company’s ambitious vision for the next 6 months as it seeks to empower individuals with smarter, more personalized approaches to health and nutrition.Learn more about VersaWare.https://versaware.io/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Andrew Foy, a cardiologist at Penn State Health, returns to the show to unpack the findings of his JAMA publication exploring industry payments in medicine and their influence on clinical practice. He examines how financial relationships with the industry may shape guideline recommendations, alter quality-of-care metrics, and contribute to potentially inappropriate prescribing practices, particularly in cases of expanded indications. Together, Chadi and Dr. Foy consider critical questions about whether medical societies should face the same scrutiny as individual physicians and whether backlash against industry involvement in healthcare is disproportionate compared to other sectors.Read the JAMA research letter on COIs.https://jamanetwork.com/journals/jama/fullarticle/2816900#google_vignetteCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Lecia Sequist, an expert in lung cancer and early detection, and Dr. Jeff Yang, a renowned thoracic surgeon, join Chadi to unravel the complexities of early lung cancer detection. Together, they explore the nuances of lung cancer screening, including the challenges of overdiagnosis and managing false-negative and false-positive results. The discussion delves into cutting-edge advancements like multi-cancer early detection tests, current patient screening eligibility criteria, and the critical factors contributing to low screening rates, such as accessibility barriers. They end on a note to raise awareness about the importance of lung cancer screening, emphasizing its safety, simplicity, and potential to save lives.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Maz Jobrani, star standup comedian and actor, joins the show to share his career journey and his beginning as an immigrant turned comedian and celebrity. Maz shares his sister's journey when diagnosed with breast cancer at a very young age. He opens up with details on challenges of being one of her caregivers and how he balanced comedy with tragedy. His sister catalogued her journey in a documentary available on Amazon Prime, titled "Everything Must Change," that is a must-watch. Maz and Chadi celebrate his sister's life and highlight how "The Cancer Journey" addresses all elements pertaining to the unfortunate journey patients and families must undertake.Find out more about Maz Jobrani.https://www.mazjobrani.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Dr. Matt Davids, Director of Clinical Research in the Division of Lymphoma at Dana-Farber Cancer Institute, to unpack the latest breakthroughs in leukemia and chronic lymphocytic leukemia (CLL) from the ASH annual meeting. A pioneer in CLL treatment, Dr. Davids recounts the development of venetoclax, a transformative therapy he helped bring to clinical use over a decade ago, setting the stage for discussions on emerging updates. Together, they explore advancements in BTK inhibitors across three distinct classes, the potential of novel targeted therapies, innovative combination regimens, and the shifting paradigms in treating blood cancers, including a nod to the latest clinical trials of high potential. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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As the holidays approach, questions about maintaining nutrition, wellness, and a healthy lifestyle take center stage. Australian nutrition icons Kim Morrison and Cyndi O'Meara join Chadi to explore vitalistic principles that emphasize natural health approaches without relying on medication. They dive into how the holiday season amplifies mental health and nutritional struggles and share actionable strategies to tackle these challenges beyond mere willpower. With an anthropological lens, they break down how understanding your unique body can guide you to maintain a healthy weight, improve overall health, and develop lasting habits. The conversation also provides practical tips for identifying high-quality ingredients and making mindful food choices that support your wellness goals. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Leading into the ASH Annual Meeting, Dr. Kami Maddocks, professor in the Division of Hematology at The Ohio State University and medical director of infusion services at The James Comprehensive Cancer Center, provides an in-depth analysis of advancements in non-Hodgkin lymphoma care, with a focus on aggressive B-cell lymphoma. She explores the evolving roles of immunotherapies like CAR-T cells and bispecific antibodies in high-risk patient populations, discusses the impact of cell-of-origin testing on frontline treatment decisions, and evaluates the latest data guiding choices between R-CHOP, transplant, and CAR-T therapy after first relapse. Dr. Maddocks also highlights the promise of BTK inhibitors and maintenance approaches in transforming patient outcomes, offering insights into the future of lymphoma treatment. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Vivek Subbiah returns for another edition of Vivek's Takes, sharing his insights on key updates from ESMO Congress 2024, including breakthroughs in neuroendocrine tumors, gastric cancer, and non-small cell lung cancer. He also delves into the highlights of his AACR debate on integrating early cancer detection with AI, arguing for the transformative potential of humans with AI versus the readiness of AI today. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi welcomes Dr. Andrea Apolo, an internationally recognized leader in bladder cancer research from the National Cancer Institute. Dr. Apolo shares her expertise on recent advancements in urothelial cancer therapy, including key breakthroughs in checkpoint inhibition that have marked a significant turning point in treatment. The conversation delves into optimal sequencing and combination strategies for checkpoint inhibitors, contrasts in treatment approaches between early-stage and late-stage disease, and the evolving landscape of bladder-sparing options. Dr. Apolo also provides an in-depth look at the comprehensive process of designing, executing, and publishing impactful clinical research, highlighted by her latest publication in The New England Journal of Medicine.Read more about her NEJM trial.https://www.nejm.org/doi/abs/10.1056/NEJMoa2401726 Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Joe Mikhael, Chief Medical Officer of the International Myeloma Foundation (IMF) and Professor at TGen, takes us beyond his medical career to explore the personal experiences that have shaped his journey in oncology. Dr. Mikhael discusses the IMF’s targeted strategies for reducing health disparities among diverse ethnic and racial groups affected by myeloma, shedding light on specific initiatives aimed at improving access and outcomes. He also dives into his role in medical education, where he mentors the next generation of oncologists through innovative fellowship programs, advancing research, and fostering a more inclusive approach to cancer care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Tom Beer, Chief Medical Officer of the Multi-Cancer Early Detection (MCED) program at Exact Sciences, delves into the groundbreaking science behind MCED tests, which use advanced biomarkers for early detection of multiple cancer types. He explains who may be eligible for these tests, how to interpret results to avoid unnecessary intervention from over-detection, and the varying sensitivity levels of MCED tests across different cancers. Additionally, Tom shares insights into the Falcon trial – a major real-world study assessing a MCED test clinical performance and potential impact on early cancer detection and patient outcomes.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In this special episode, Chadi gives up the microphone to guest host Kelly Ryerson, who takes over the show asking questions about Chadi's new book "The Cancer Journey."What inspired the book writing? What methods are used? Who is the target audience? What did the author learn? And what did he aim to achieve?Written for everyone who wants to learn more about cancer, this discussion highlights behind-the-scenes information on Chadi's latest achievement.View more and order “The Cancer Journey.”chadinabhan.com/the-cancer-journey/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Jon Chait never thought he would get cancer, but one day he found he had it. As he navigates his journey alongside his caregiver and wife Heather, he shares with Chadi the good and the bad, the ups and downs, and what he encounters in a broken, complex healthcare system.A fitting episode as Chadi launches his book "The Cancer Journey." It is a must listen to anyone navigating the system. Is it truly patient-centric as advertised?You be the judge.View more and order “The Cancer Journey.”https://chadinabhan.com/the-cancer-journey/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Kathy Giusti, founder of the Multiple Myeloma Research Foundation (MMRF) and a two-time cancer survivor, opens up about her first diagnosis and the life-changing conversation with her primary care doctor. She reflects on the overwhelming "age of information," which often leads patients to more questions than answers, and shares her strategies for dealing with the loss of control that comes with a cancer diagnosis. Kathy also talks about the importance of identifying what truly matters, placing personal priorities in plain sight as daily reminders. She delves into the potential next breakthrough in multiple myeloma research, her success in engaging patients in MMRF’s direction, and offers heartfelt advice for families on when and how to tell children about a cancer diagnosis, as well as other important points through the cancer journey, drawing from her own deeply personal experiences.Read more about the Kathy Giusti story.https://www.statnews.com/2024/09/03/multiple-myeloma-kathy-guisti-fatal-to-fearless-patient-advocate-research-fundraiser/Find out more about Kathy’s book “Fatal to Fearless.”https://www.kathygiusti.com/bookCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Joe Lennerz, Chief Scientific Officer of BostonGene and a pathologist by training, joins Chadi to break down next-generation sequencing (NGS) in simple terms, discussing why some patients undergo NGS while others do not, along with its advantages and limitations. He also explores the impact of NGS on treatment pathways, the practicality of minimal residual disease (MRD) detection, liquid biopsy, and circulating tumor DNA (ctDNA), and whether immediate action should be taken after MRD detection. Additionally, Dr. Lennerz examines multi-cancer early detection technologies, who should be tested, and the future need for regulatory oversight in this rapidly advancing field.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Sanjay Patel of Weill Cornell and Dr. Greg Goldgof of Memorial Sloan Kettering dive into the transformative role of AI in modern pathology. They discuss how large language models are enhancing diagnostic workflows, expediting report synthesis, and shaping the future of patient care. The conversation also touches on the complex training required to ready AI systems for clinical use, the areas of pathology most impacted by AI today, and how this technology is being integrated into the education of future pathologists.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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David Canes, CEO of WellPrept and a Boston-based urologist, joins the show to share the story behind his innovative platform designed to reduce physician burnout. He explains how WellPrept empowers doctors to streamline patient education by organizing and delivering tailored materials before the first visit, allowing for more personalized and efficient consultations. David also touches on his entrepreneurial journey, the platform's future expansion beyond urology, and the broader impact WellPrept could have across all medical specialties.Find out more about WellPrept.https://wellprept.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Graduating fellows Jennifer Marks and Megan Melody join the show to discuss the challenges of navigating the job search during fellowship. They share insights on when to start looking for positions, the importance of networking through mentors and conferences, and how to handle geographic limitations in the job market. The conversation also covers key interview strategies, tips for compensation negotiations, and what to do when asked to present during an interview—especially when things don't go as planned.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Yelak Biru, President and CEO of the International Myeloma Foundation (IMF), joins the show to share his remarkable personal and professional journey. After immigrating to the US from Ethiopia, Yelak was diagnosed with multiple myeloma at the age of 26, setting him on an extraordinary path as both a survivor and a passionate advocate for myeloma patients. He discusses pivotal moments in his treatment, including seeking second opinions, utilizing groundbreaking therapies like CAR-T, and his ongoing decision to reject a transplant. Now leading the world’s first and largest nonprofit dedicated to improving the lives of those impacted by multiple myeloma, Yelak shares his vision for expanding IMF's global outreach, advancing research, and empowering patients and caregivers worldwide.Learn more about the IMF.https://www.myeloma.org/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Anish Koka, a cardiologist at Jefferson Health, returns to the show for the first time since the inaugural episode in October 2020. With a sharp focus on healthcare policy, he delves into the impact of the Affordable Care Act on his practice, critiques the influence of political biases in academia, and shares his bold ideas for making healthcare insurance accessible and affordable. Dr. Koka also offers insights on prior authorization alternatives, the Inflation Reduction Act, 340B, and much more in this thought-provoking and, at times, contentious discussion.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Ziad Bakouny, MD, MSc, and Nazli Dizman, MD, return to the show to discuss the progress made for International Medical Graduates (IMGs) within the American Society of Clinical Oncology (ASCO). Building on their previous conversation, they explore the origins of their initiatives at ASCO 2022, the goals for integrating IMGs into successful medical careers in the US, and the significant challenges posed by Visa constraints. Together, they expand on the unique hurdles faced by IMGs in oncology, how these compare across specialties, and the ongoing efforts to support IMGs.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Russell Gong, President and CEO of Cabinet Health, and Eric Lessard, Vice President of Pharmacy, to explore their mission to revolutionize the healthcare industry with sustainable practices. They discuss the inspiration behind Cabinet Health, the significance of reducing plastic waste with their eco-friendly refillable medicine system, the startup's success metrics, their customer engagement strategies, and the unique features of their packaging. Additionally, they share insights from their transformative experience on Shark Tank and how it helped propel their vision for a greener healthcare future.Find out more about Cabinet Health.https://cabinethealth.com/Watch the Cabinet Health pitch on Shark Tank.https://www.youtube.com/watch?v=Cf4n8UCp4r4Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Ishwaria Subbiah, Executive Director for Cancer Care Equity and Professional Wellness at the Sarah Cannon Research Institute, joins Chadi to delve into the complexities of professional wellbeing and burnout in the healthcare field. She explores the prevalence of burnout, the concept of "learned helplessness," and effective strategies for improving organizational wellness and resilience among healthcare professionals.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Christian Rolfo, MD, PhD, of Mount Sinai Medical Center, explores the science and clinical applications of liquid biopsies, including circulating tumor DNA. With Chadi, he explains how this cutting-edge approach compares to traditional tissue samples in terms of concordance, sensitivity, and specificity, and expands on the methods used to distinguish signal from noise in liquid biopsy results. Dr. Rolfo discusses which thoracic patients should receive liquid biopsies and the optimal timing within their care journey. He also covers the clinical decisions informed by liquid biopsy data, such as advising on adjuvant therapy, and debates the potential role of liquid biopsies in screening and early detection for healthy individuals.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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It's July/August and this is the time when residents and fellows start their new chapter of their lives.In this special episode, Chadi tackles the fellowship application process using the "hematology/oncology" fellowship as an example, while keeping the conversation broad to most other fellowships in other disciplines. To better understand the process and the issues, he has invited a fellowship program director and a fellow applicant.Marc Braunstein, fellowship program director at NYU Langone Health, and Megan Melody, a fellow at Northwestern, discuss the intricacies of applying for internal medicine fellowships. They delve into what makes a strong application, the various types of fellowship programs, and the perspectives of both applicants and program directors in the matching process, including how to write a compelling personal statement, secure strong references, and choose which programs to visit, as well as so much more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is joined by Drs. Rana McKay and Petros Grivas to discuss the latest genitourinary oncology research updates from the 2024 ASCO Annual Meeting, covering topics such as the prognostic ability of KIM-1 in kidney cancer, patient-reported outcomes from enfortumab vedotin/pembrolizumab treatment, and the final overall survival update from the JAVELIN Renal 101 trial. The conversation also delves into studies on IO/TKI biomarkers, adaptive trials with ctDNA, and the latest findings from trials like KEYNOTE-426, CLEAR, PSMAfore, and SURE-01.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In this exclusive interview, Chadi welcomes Dr. Patrick Soon-Shiong, a Chinese immigrant who grew up under apartheid in South Africa and rose to become one of the world's most successful physician executives. Now the CEO of ImmunityBio, Dr. Soon-Shiong opens up about his remarkable journey. He shares what inspired him to pursue medicine, his entrepreneurial ventures, his move to the United States, and the story of his first investment. He discusses creating the groundbreaking chemotherapy drug Abraxane, which led to the formation of Abraxis, later acquired by Celgene, now part of BMS. He also expounds on his most recent FDA-approved drug, Anktiva, for bladder cancer. With complete candidness, Dr. Soon-Shiong reflects on his challenging upbringing, the discrimination he faced, and how he overcame these obstacles to achieve great success. He and Chadi explore life lessons, leadership styles, and a range of topics including Kobe Bryant, Gavin Newsom, COVID-19, the first pancreatic transplant, the acquisition of the Los Angeles Times, and his public feud with his brother.This 2024 podcast episode offers an unparalleled glimpse into the life of a highly public and inspiring figure and is one you’ll want to listen to more than once and share with everyone you know.Read more about Dr. Soon-Shiong.https://immunitybio.com/our-founder/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Drs. Balazs Halmos and Lecia Sequist delve into the groundbreaking updates from the 2024 ASCO Annual Meeting. With Chadi, they reveal game-changing insights on EGFR-mutated lung cancer from the LAURA trial, small-cell lung cancer upgrades from the ADRIATIC trial, important revelations in ALK mutation research, innovative combination therapies, ctDNA results from the ADAURA trial, and conclude with the relevance of the KRYSTAL-12 study.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Vivek Subbiah, MD, Chief of Early-Phase Drug Development at Sarah Cannon Research Institute, kicks off his new series on Healthcare Unfiltered, “VIVEK’S TAKES,” in which he will provide his expert feedback on the importance and lasting effects of research presented at the top medical conferences in the world.In response to the 2024 ASCO Annual Meeting, Dr. Subbiah shares the themes he sees being developed in multiple cancer subspecialties, including breast, lung, and pancreatic, as well as the research-driven benefits of receiving care on clinical trials and early palliative care via telemedicine.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is joined by Kate Dilligan, Founder and CEO of Cooler Heads Care, the manufacturer of a portable scalp cooling system authorized for adults 21 and older undergoing chemotherapy for a solid tumor. Kate shares her personal journey from being diagnosed with breast cancer to becoming an entrepreneur driven by a mission to help women undergoing chemotherapy mitigate the side effect of hair loss. Kate discusses the science behind the scalp cooling system and its effectiveness in preserving hair. She also delves into her innovative business model that supports infusion centers in remaining profitable, her journey in securing investors, and the future goals of Cooler Heads Care.Find out more about Cooler Heads.https://coolerheads.com/Read Kate’s profile in Forbes.https://www.forbes.com/sites/maggiemcgrath/2022/12/28/meet-the-entrepreneur-helping-women-undergoing-chemo-keep-their-hair/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with David Krissman, a journalist and filmmaker whose passionate advocacy for kidney transplant and dialysis patients led him to create the groundbreaking podcast documentary series, "The Great Social Experiment." Krissman shares the harrowing personal story that inspired his film script, website, and podcast, exposing the stark financial incentives driving the U.S. healthcare system's approach to kidney transplantation and dialysis. Designed specifically for patients, his work offers crucial insights to help them navigate the often perilous landscape. The conversation broadens to address the challenges of routine clinical care, contrasting the U.S. system with those of other countries, providing a comprehensive look at the ongoing struggle for better, more equitable healthcare.Find out more about The Great Social Experiment.https://www.thegreatsocialexperiment.net/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Ronald Chapman, LLM, Shareholder and Chairperson of White Collar Defense & Government Investigations at Chapman Law Group, delves into the intricate intersections of law and daily life, highlighting the subspecialized nature of healthcare law and his primary areas of focus within this field. He offers insights into his strategic choices between judge and jury trials, providing a nuanced perspective on opioid prescriptions, and delineates the fine line between lawful and unlawful practices. Ronald also unpacks the complex legal nuances involved in cases of unlawful opioid prescriptions, offering listeners a deep dive into the legal challenges and considerations in these critical issues.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Shaalan Beg, MD, MBA, FASCO, and Noelle K. LoConte, MD, FASCO, join Chadi to delve into the contentious relationship between alcohol consumption and cancer. Drawing from their expertise and insights, they navigate through the complexities of discerning causation from association in this context, shedding light on why a randomized controlled trial might never conclusively prove this link. From deciphering the threshold of alcohol intake that elevates the risk of 7 types of cancer to addressing the challenge of convincing the public to heed the data, Drs. Beg and LoConte explore the nuances of risk assessment and drinking in social situations, including medical conferences.Read more about this topic.https://connection.asco.org/blogs/examining-controversy-surrounding-alcohol-promotion-oncology-events-virtue-signaling-or-cancerCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is rejoined by special guest Dr. Pamela Kunz, Editor in Chief of the groundbreaking new publication, JCO Oncology Advances. Dr. Kunz, known for her expertise in gastrointestinal cancers, shares the story of how she landed the prestigious role, offering insights into the rigorous interview process. She discusses her innovative approach to generating interest in the peer-review process and outlines the journal's ambitious goals to promote open-access publishing and collaborate closely with the esteemed Journal of Clinical Oncology. With a wealth of experience, Dr. Kunz reveals the type of individuals who will comprise the journal's Editorial Advisory Board as well as the proposed new journal sections that are novel to medical publishing.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi sits down with Dr. Chandana Banerjee, a trailblazer in palliative and hospice care, serving as the Dean, Director, and Designated Institutional Official of Graduate Medical Education at the City of Hope Comprehensive Cancer Center. With a remarkable career dedicated to improving end-of-life care, Dr. Banerjee shares insights on how to infuse every aspect of patient care with the same passion and hope found in palliative settings. From navigating the challenges of funding and visibility in the medical community to offering fellowship opportunities emphasizing communication nuances in this critical stage of care, Dr. Banerjee provides invaluable perspectives. Together, they shed light on common pitfalls healthcare professionals face in end-of-life care, strategies for breaking through patient denial, and much more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is joined by Stephanie Chuang, a remarkable patient advocate, survivor of non-Hodgkin lymphoma, and the visionary behind The Patient Story, a curator of patients stories and resources for people diagnosed with cancer. Stephanie shares her journey from a surprise diagnosis to the genesis and execution of The Patient Story during her chemotherapy treatment. Learn how she garnered viewers on her website and YouTube channel, driven by her mission to curate information and resources to inspire hope. She delves into the impact of social media on patient understanding and emotional management, explores the dynamics in the physician's office that often leave patients dissatisfied, and uncover the meticulous process of choosing and vetting stories featured on her platform.View The Patient Story website.https://thepatientstory.com/donate/View The Patient Story YouTube channel.https://www.youtube.com/@ThePatientStoryCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi and guest Dr. Manmeet Ahluwalia, Deputy Director, Chief Scientific Officer, and Chief of Solid Tumor Medical Oncology at Miami Cancer Institute, delve into the latest breakthroughs in primary brain cancers. As a distinguished expert in brain metastases and primary brain tumors, Dr. Ahluwalia provides invaluable insights into clinical trial design, enrollment challenges, and the complexities of brain tumor development. Together, they explore the landscape of surgical and therapeutic interventions, uncovering advances in survival rates, quality-of-life enhancements, and promising therapeutic agents targeting specific mutations, as well as mechanisms of treatment resistance and the ongoing pursuit of effective solutions.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi delves into the realm of AI and its transformative impact on drug development with Adam Petrich, MD, Chief Medical Officer of QuantHealth, who unveils the AI solutions crafted by QuantHealth, aimed at simulating and predicting clinical trial outcomes to enhance the success rates of trials. Drawing from his expertise, Dr. Petrich sheds light on the integration of AI in the clinical trial creation process, offering insights into predicting investigational treatment efficacy against standard of care treatments. He also explores the delicate balance between sensitivity and specificity, and delves into the meticulous validation processes employed to ensure model accuracy.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Aaron Goodman, who started a petition that gathered over 20,000 signatures to end the MOC back in July 2023, found himself suddenly reported as NOT CERTIFIED by the ABIM in the specialty he practices and teaches (hematology). When he called the ABIM, he was told he needed to pay thousands of dollars in back fees for the Internal Medicine Board that he did not want to keep, as he is a specialist in bone marrow transplant and hematology.The ABIM advised that unless he pays these fees, he will be deemed “not certified,” which threatens his ability to see patients at his own institution.Aaron was shocked and so was Chadi.The entire story is here. Learn what happened, what is next, and what can be done.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Grace Cordovano, a distinguished Board Certified Patient Advocate and the visionary founder of Enlightening Results, as well as the co-Founder of Unblock Health, delves into her personal journey, recounting her own wrongful diagnosis of advanced lymphoma and how it propelled her into patient advocacy. Drawing from her extensive experience, she sheds light on the diverse array of individuals who seek her guidance and the multifaceted challenges they face, from navigating the complexities of tumor boards to grappling with insurance denials and prior authorizations. Dr. Cordovano also illuminates her innovative approach, harnessing the power of AI to provide patient-centric counsel and support. With a deep commitment to advocating for patients at every stage of their healthcare journey, she shares insights into her involvement in end-of-life care and offers invaluable perspectives on advocating for patients in the contemporary era.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is joined by Simon Arkell, Co-Founder and CEO of Ryght, a pioneering company in the healthcare ecosystem that specializes in producing generative AI solutions that cater specifically to the needs of drug companies. Simon sheds light on the nuances between AI and traditional machine learning models, highlighting Ryght's innovative approach to making generative AI both accessible and secure. He expands on the intricacies of data synthesis, drawing from diverse sources to craft individualized models for each client. Simon further shares how customer feedback has been instrumental in refining Ryght's offerings, ultimately shaping the future of healthcare innovation.For more information about Ryght, visit their website.https://www.ryght.ai/about-usCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Paul Teirstein, President of NBPAS.org, joins Chadi to highlight and reveal how the National Board of Physicians and Surgeons (NBPAS) is challenging the status quo of board certification for all medical practitioners. With a mission to advocate for physicians and combat the monopoly of Maintenance of Certification, Dr. Teirstein explains how NBPAS provides a refreshing alternative for continuous board certification.Visit the NBPAS website.https://nbpas.org/View Dr. Teirstein debating Dr. Lois Margaret Nora of the American Board of Medical Specialties.https://www.youtube.com/watch?v=_fc3BQ-9yMMView Dr. Teirstein’s MOC presentation.https://www.youtube.com/watch?v=h1vw2RPCd1sCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In this ASCO-GI research special, Dr. Bekaii-Saab of Mayo Clinic provides an insightful and comprehensive roundup of the most groundbreaking studies unveiled at the ASCO GI 2024 meeting. Delving into the realm of hepatocellular carcinoma, he dissects the pivotal previously-reported data from IMbrave050 and ASCO GI findings from EMERALD-1. Then, he sheds light on developments in colorectal cancer, exploring the impact of KEYNOTE-177 and CheckMate 8HW. Moreover, Dr. Bekaii-Saab explores the latest advancements in minimal residual disease assessment with a focus on studies like BESPOKE and GALAXY, as well as the prognostic value of ctDNA assessment showcased in COBRA.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Pedro Barata, Director of the Clinical Genitourinary Medical Oncology Research Program at UH Seidman Cancer Center, provides an exclusive round-up of the most groundbreaking and practice-changing research unveiled at the ASCO GU 2024 meeting. With expertise and insight, he delves into pivotal studies such as CheckMate 914 Part B and KEYNOTE-564, exploring their implications for kidney cancer. The episode further unravels the transformative findings from the AMBASSADOR study, shedding light on adjuvant immunotherapy in bladder cancer; genetic testing and FGFR advancements in bladder cancer; life-prolonging therapies and radioligand therapies in castration-resistant prostate cancer; and the latest in minimal residual disease research.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Joining host Chadi is the esteemed James LaBelle, MD, PhD, Associate Director of Pediatrics and Director of the Stem Cell and Cellular Therapy Program at the University of Chicago. Dr. LaBelle elucidates the complexities of sickle cell disease, unraveling the devastating impact it has on individuals. The episode delves into various treatments and approaches to combat this formidable disease, including bone marrow transplant and the groundbreaking use of CRISPR-Cas9 technology. LaBelle shares insights into the recent research breakthroughs, citing the remarkable research report published in the New England Journal of Medicine, showcasing the successful application of CRISPR-Cas9 for sickle cell disease. This episode serves as a gateway into the promising future of genetic therapies.Read Dr. LaBelle’s publication on CRISPR-Cas9 in NEJM.https://www.nejm.org/doi/full/10.1056/NEJMoa2215643Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In a poignant episode, USA Today investigative journalist Emily Le Coz unravels the heart-wrenching narrative of Ashleigh Anderson, a CVS pharmacist whose tragic demise serves as a cautionary tale of overwhelming stress in the workplace. Emily shares her motivations behind delving into the pervasive issue of burnout in retail pharmacy and sheds light on the very real threat it poses. She recounts the details of the Ashleigh Anderson story, where the toxic culture within retail pharmacy played a pivotal role in a life lost to the pressures of the job. Together, Chadi and Emily Le Coz navigate the profound implications of burnout, exploring its dangers and the urgent need for systemic change within the retail pharmacy landscape. This episode serves as both a tribute to Ashleigh Anderson and a rallying cry for reform in an industry grappling with the devastating consequences of unchecked workplace stress.Read more about the Ashleigh Anderson story.https://www.usatoday.com/story/news/investigations/2024/02/08/cvs-pharmacist-ashleigh-anderson-death-rallying-cry/72406578007/Read another piece by Emily Le Coz.https://www.usatoday.com/story/news/investigations/2023/10/26/pharmacy-chains-dangerous-conditions-medication-errors/71153960007/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Joining host Chadi is a trio of esteemed guests – Drs. Andy Evans, Matt Maurer, and Susan Parsons – of the HoLISTIC (Hodgkin Lymphoma International Study for Individual Care) Consortium. In this riveting conversation, they delve into the consortium's pioneering efforts, bringing together an international team of experts to scrutinize the multifaceted dimensions of Hodgkin lymphoma, spanning prognosis, epidemiology, treatment, survivorship, and health outcomes across all age groups. The discussion circles around consensus protocols for treatment, referral pathways, and clinical trials, probing the necessity of transplants in the era of novel therapeutics and the creation of predictive models tailored to individual patient needs. Tune in to hear about the meticulous efforts invested in building the HoLISTIC portal, automating data migration, and navigating the challenges and progress in predictive modeling for treatment selection, response, and failure. This episode offers a captivating exploration of how collaboration, technology, and data analysis converge to shape the future of Hodgkin lymphoma care.Find out more about the HoLISTIC Consortium.https://www.hodgkinconsortium.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In the latest installment of the ABIM Maintenance of Certification (MOC) saga on Healthcare Unfiltered, the fiery aftermath of Aaron Goodman's groundbreaking petition to dismantle the ABIM MOC takes center stage. Joined by recurring guests, the outspoken Drs. Wes Fisher, Vincent Rajkumar, and Aaron Goodman himself, Chadi dives deep into the shifts within the medical landscape over the past six months. The conversation unfolds with a critical analysis of medical societies' responsiveness to the petition, exploring whether genuine change is underway or if inertia prevails. Together, they passionately discuss the crucial role of hospital and institution-wide rejection in catalyzing a domino effect for change. The episode doesn't shy away from the legal battlefield either, delving into the multiple class-action anti-trust cases against ABIM MOC. Tensions rise throughout the conversation, but it concludes with a collective focus on the next steps to propel this movement forward.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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In a highly-anticipated comeback, Dave Feldman, the seasoned senior software engineer and entrepreneurial mind, delves into uncharted territories of the keto diet, cholesterol dynamics, and lipids, unveiling a riveting discourse intricately intertwined with a novel cardiac study. Feldman unfolds the layers of his personal journey with the keto diet, evolving into a recognized authority on lipids. He showcases the intriguing sequence of events that propelled him to design a study involving cardiac tests and a cohort of 100 patients committed to a low-carb, keto lifestyle for over a year. Could this study revolutionize the way cardiologists and primary care providers approach cholesterol management? Will it unveil evidence challenging the conventional prescription of statins to lower LDL? Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Salma Jabbour, MD, Professor and Vice Chair of Radiation Oncology at Rutgers Cancer Institute, provides an invaluable perspective rooted in her extensive experience and passion for radiation oncology. Dr. Jabbour delves into the transformative changes witnessed in radiation oncology over the past two decades, contrasting its trajectory with precision oncology. She shares compelling insights into the PROSPECT trial's innovative approach of omitting radiation therapy entirely for rectal cancer patients, emphasizing the "impressive" results unveiled in the study. Then, the New York Times articles characterizing radiation as "brutal" for patients in this context is considered, and Dr. Jabbour navigates the complexities, challenges, and potential paradigm shifts these findings might signal for the field.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content.www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube.www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Highlighting the complex and contentious world of non-compete clauses within the medical field, Dr. David Lankford, a pediatric intensivist, made headlines after challenging a non-compete clause in his contract with Lutheran Medical Group in Indiana. His lawsuit not only raises questions about the legality and ethical implications of such clauses, but also tests a new state law regarding physician non-competes. Dr. David Lankford is joined by Alex Pantos, an associate attorney integral to his case. Together, they provide deep insights into the legal intricacies, broader implications for healthcare professionals, and the potential impact of this legal battle on the medical community. The nuances and debates surrounding this pivotal case may reshape the landscape of physician contracts and professional mobility.Read more about the lawsuit.https://www.wfyi.org/news/articles/this-doctors-lawsuit-puts-a-new-physician-noncompete-state-law-to-the-test-heres-whats-at-stakeCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Making his return to the show is Dr. Robert Califf, the current FDA Commissioner, this time to break down and offer insights into the Administration’s contentious accelerated approval pathway. Dr. Califf expands on the criticisms and concerns surrounding surrogate endpoints and confirmatory trials within the accelerated approval process, shedding light on the ongoing dialogue between the Administration and manufacturers regarding these crucial trials. He navigates through the intricacies of the Food and Drug Omnibus Reform Act, offering perspectives on the global use of drugs and devices post-negative results in confirmatory trials. Dr. Califf also emphasizes the imperative need for a revamped post-market evidence generation system while exploring various avenues for achieving this critical transformation.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Drs. Hossein Borghaei and Tony Calles dissect the pivotal abstracts and cutting-edge data unveiled at ESMO 2023, spotlighting the transformative landscape of lung cancer treatment. From exploring innovative immunotherapy combinations to the promising prospects of antibody-drug conjugates, they navigate through the complexities of neoadjuvant and adjuvant sequencing, shedding light on optimal therapeutic strategies. With a keen focus on targeted therapies and an array of other compelling studies, Drs. Borghaei and Calles decode the implications of these advancements, offering invaluable insights into reshaping the future of lung cancer care.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Steve Stavs, a “pro biohacker” and “health futurist,” unveils his model to combat chronic diseases by addressing root causes, while exploring Eastern medicine's approach to preventive care and its current standing in research and empirical evidence for complementary interventions. As a pro biohacker, Stavs shares insights on optimizing whole-body performance and health, highlighting the impact of internal and external factors on chronic diseases and differentiating between "getting old" and the process of "aging." With Chadi, he delves into dietary nuances, distinguishing between organic and processed foods, sodas, and their implications for overall health, presenting a holistic view of Chinese and Eastern medicine's potential in fostering a healthier lifestyle.Read more about Steve Stavs.https://stevestavs.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Ameish Govindarajan, MD, a Hospice and Palliative Medicine fellow at Memorial Sloan Kettering Cancer Center, shares his journey outlined in the Journal of Clinical Oncology's Art of Oncology piece, "Chasing Milestones," which sheds light on his personal experience as a patient diagnosed with stage 4 NSCLC. Dr. Govindarajan shares how this diagnosis influenced his career trajectory, including the pivotal decision to switch oncologists due to a lack of connection with his initial clinician. Together, he and Chadi explore the critical aspects of establishing trust with your healthcare provider and the indicators that signal a strong patient-physician relationship. Delving into his path toward enrolling in an early-phase clinical trial, Dr. Govindarajan provides valuable insights into navigating treatment decisions. Moreover, he discusses how his own care journey has shaped his approach to patient interactions, offering a unique perspective on compassionate and empathetic healthcare delivery. Read Dr. Govindarajan’s publication in JCO.https://ascopubs.org/doi/full/10.1200/JCO.22.01379Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Chadi is joined by experts Jennifer Wargo, MD, Nazli Dizman, MD, and Sumanta (Monty) Pal, MD, from The University of Texas MD Anderson Cancer Center and City of Hope, to unravel the intricate relationship between the microbiome and cancer. Delving into the historical context and evolution of this connection in oncology, they share insights on manipulating the microbiome and its potential impact on specific cancers, discuss the role of dietary interventions in cancer research and management, and more. Together, they address skepticism surrounding the microbiome's significance in cancer, offering evidence-based arguments that demystify misconceptions and present compelling facts about the microbiome's crucial role in understanding and treating cancer.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Allison Rosenthal, Assistant Professor of Medicine and a driving force behind Mayo Clinic's Adolescent and Young Adult Cancer Program, candidly shares her personal odyssey as a leukemia survivor during her young adulthood and how this transformative experience steered her career toward advocating for AYA cancer patients. She navigates through complex topics such as survivor guilt, identifying when survivorship begins in the patient journey, and the crucial decision-making between pediatric and adult specialists based on patient age. Dr. Rosenthal also sheds light on the indispensable role of financial counseling and support services for AYA patients while unraveling ongoing research endeavors in this setting.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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Dr. Clifford Hudis, the ASCO CEO, shares ASCO's approach to the continued ABIM-MOC saga. With many oncologists expressing their angst about the MOC process, ASCO, under his leadership, approached the situation methodically, sending a survey to its members to quantify the problem and explore next steps. This is the FIRST time the results of this survey are shared publicly. Learn about Dr. Hudis's inspiring career journey, his leadership style, and how he and ASCO are addressing this MOC Dilemma. This is a must-listen episode; be the first to know what has happened within ASCO and what the next steps might be.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA]]>

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